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Table 3 Aneuploidy in SAEC cell exposed to MWCNT material

From: Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells

Treatment Total Aneuploidy (%) Chromosome1 (%) Gain (%) Loss (%) Chromosome 4 (%) Gain (%) Loss (%)
Control 9 ± 4 7 ± 3 4 ± 2 3 ± 3 6 ± 3 4 ± 1 3 ± 2
V2O5 41 ± 11* 33 ± 13* 13 ± 4 20 ± 11 19 ± 9 9 ± 3 10 ± 6
MWCNT-7 (μg/mL) 0.024 59 ± 13*+ 41 ± 5* 10 ± 6 31 ± 11¥ 37 ± 19* 19 ± 24 18 ± 7
0.24 59 ± 13* 45 ± 8*+ 13 ± 10 32 ± 16¥ 35 ± 17* 13 ± 13 21 ± 8
2.4 61 ± 7* 45 ± 16* 7 ± 2 39 ± 18¥ 40 ± 13* 9 ± 8 31 ± 13¥
24 67 ± 3* 49 ± 7* 9 ± 2 40 ± 6¥ 48 ± 3*+ 8 ± 5 40 ± 8¥
MWCNT-HT (μg/mL) 0.024 44 ± 14*+ 32 ± 5* 18 ± 10 14 ± 6 29 ± 13* 14 ± 8 15 ± 7
0.24 45 ± 13* 31 ± 1*+ 14 ± 3 17 ± 3 29 ± 16* 19 ± 16 10 ± 0
2.4 51 ± 6* 38 ± 7* 14 ± 11 24 ± 13 29 ± 10* 15 ± 9 15 ± 7
24 61 ± 7* 45 ± 6* 8 ± 6 36 ± 8¥ 38 ± 8* 10 ± 7 28 ± 14¥
MWCNT-ND (μg/mL) 0.024 48 ± 18* 36 ± 8* 14 ± 8 21 ± 5 30 ± 15* 16 ± 9 15 ± 7
0.24 46 ± 10* 33 ± 4* 9 ± 5 23 ± 7¥ 29 ± 13* 17 ± 12 12 ± 2
2.4 51 ± 6* 42 ± 7* 11 ± 10 31 ± 11¥ 28 ± 13* 15 ± 5 13 ± 10
24 56 ± 14* 42 ± 8* 16 ± 13 26 ± 8 34 ± 15*+ 16 ± 15 18 ± 4
  1. This table represents the percentage of aneuploidy in SAEC cells exposed to each MWCNT material and 0.316 μg/mL V2O5, positive control, for 24 h. Percentage of total aneuploidy is representative of aneuploidy of chromosomes 1 and 4 combined and based on the total number of cells analyzed. Percentage of aneuploidy was also separated by chromosome and a loss or gain of either chromosome 1 or 4 was also recorded as a percentage of total cells. * indicates significantly different from control, p < 0.05. ¥ indicates significantly different from counterpart MWCNT materials, p < 0.05. + indicates significantly different from each other, within treatment group, p < 0.05. ± SD