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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Protein target identification and toxicological mechanism investigation of silver nanoparticles-induced hepatotoxicity by integrating proteomic and metallomic strategies

Fig. 4

Internalization of AgNPs and intracellular soluble Ag-components in AgNPs-treated HepG2 cells. a Cellular delivered dose of AgNPs at 2, 4 or 8 μg/mL after 24 h-treatment (n = 3). b Soluble Ag-components of HepG2 cells treated with AgNPs at 0.6, 1, 2, 4 or 10 μg/mL for 24 h (n = 3). c Ag content of RNA, DNA and protein components in AgNPs-treated HepG2 cells at 2, 4 or 8 μg/mL for 24 h (n = 5). d Chromatograms of Ag-protein complexes from untreated and AgNPs-treated HepG2 cells at 1, 2 or 4 μg/mL for 24 h analyzed using SEC-ICP-MS. e Normalized HMW and LMW fractions from AgNPs-treated HepG2 cells at 0.01, 0.1, 0.2, 0.6, 1, 2 or 4 μg/mL for 24 h analyzed using SEC-ICP-MS (n = 3)

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