Table 2 Slopes of dose-response curves for short-lived ROS and H2O2 generated by seven silica NPs over the concentration range of 10 to 100 μg/ml
Slope | Silica nanoparticle type | ||||||
|---|---|---|---|---|---|---|---|
WetChem | FSP 5/5 | FSP 3/5 | FSP 4/5 | FSP 9/3 | FSP 11/3 | Commercial | |
Short-lived ROS (pmol H2O2 eq./μg silica) | 4.8 | 20.3 | 11.8 | 8.3 | 17 | 21 | 19.6 |
Ratio relative to WetChem (short-lived) | 1.0 | 4.2 | 2.5 | 1.7 | 3.5 | 4.4 | 4.1 |
H2O2 (pmol H2O2 eq./μg silica) | 32 | 22.9 | 26.4 | 25.3 | 50.2 | 41.7 | 43 |
Ratio relative to WetChem (H2O2) | 1.00 | 0.72 | 0.83 | 0.79 | 1.57 | 1.3 | 1.34 |
Total ROS(pmol H2O2 eq./μg silica) | 36.8 | 43.2 | 38.1 | 33.5 | 67.2 | 62.7 | 62.6 |
Ratio relative to WetChem (total ROS) | 1.00 | 1.2 | 1.00 | 0.91 | 1.83 | 1.7 | 1.70 |
Short-lived, % of total ROS | 13.0 | 47.0 | 31.0 | 24.8 | 33.9 | 33.5 | 31.3 |