Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

Table 3 Incidences of liver MT with internalized CeO₂ and TiO₂ NM at 3 weeks

MT exposure	Representative image in Fig. 4	MT with internalized NMs	Notes
Negative control	a	(1)/13	Small agglomerate detected in one of the 13 MT investigated. Due to the fact, that the material was not present in any of the other sections, it is considered as an artefact.
TiO₂–1.25 μg/ml	b	5/5
TiO₂–5 μg/ml		2/2
CeO₂–1.25 μg/ml	c	8/8
CeO₂–5 μg/ml	d	8/8

ISSN: 1743-8977