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Table 1 Cancer incidence, lung burden and Unit risk values for TiO2 nanoparticles, carbon black nanoparticles and diesel engine exhaust in chronic inhalation studies in rats [5]

From: Commentary: the chronic inhalation study in rats for assessing lung cancer risk may be better than its reputation

 

Control (filtered air)

10 mg/m3 TiO2 (P25)

11.6 mg/m3 Carbon black

(Printex90)

2.5 mg/m3 Diesel engine exhaust

Total cancer incidence (benign and malignant)

1/217

32/100

39/100

11/200

Lung burden (mg/animal at mo 24)

–

39.3

43.9

23.7

Lung burden as deposited surface area at mo 24 (m2)

–

1.89

9.96

2.54

Unit risk per μg/m3

–

2.1 × 10−5

2.22 × 10− 5

1.34 × 10− 5