Table 1 Hematological values of rats in the repeated-dose 28-day study, mean ± SD (number of animals)
From: Oral toxicity of titanium dioxide P25 at repeated dose 28-day and 90-day in rats
Summary of hematological tests from the repeated-dose 28-day study | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sex: Male | ||||||||||||||||
Test item | Group(mg/kg/day) | |||||||||||||||
G1(0) | G2(250) | G3(500) | G4(1000) | |||||||||||||
WBC1(K/μL) | 7 | ± | 2.06 | (5) | 8.09 | ± | 2.03 | (5) | 6.39 | ± | 1.94 | (5) | 7.15 | ± | 1.29 | (5) |
PMN2(K/μL) | 1.1 | ± | 0.44 | (5) | 1.17 | ± | 0.25 | (5) | 0.81 | ± | 0.35 | (5) | 1.29 | ± | 0.58 | (5) |
EO3(K/μL) | 0.07 | ± | 0.03 | (5) | 0.06 | ± | 0.02 | (5) | 0.06 | ± | 0.04 | (5) | 0.06 | ± | 0.03 | (5) |
BA4(K/μL) | 0.01 | ± | 0 | (5) | 0.01 | ± | 0.01 | (5) | 0 | ± | 0 | (5) | 0 | ± | 0 | (5) |
LY5(K/μL) | 5.66 | ± | 1.63 | (5) | 6.69 | ± | 1.91 | (5) | 5.34 | ± | 1.54 | (5) | 5.59 | ± | 1.11 | (5) |
MO6(K/μL) | 0.14 | ± | 0.06 | (5) | 0.11 | ± | 0.01 | (5) | 0.12 | ± | 0.1 | (5) | 0.14 | ± | 0.04 | (5) |
LUC7(K/μL) | 0.04 | ± | 0.02 | (5) | 0.05 | ± | 0.03 | (5) | 0.06 | ± | 0.05 | (5) | 0.05 | ± | 0.02 | (5) |
PMNP8(%) | 15.5 | ± | 3.9 | (5) | 15.1 | ± | 4 | (5) | 12.5 | ± | 2.6 | (5) | 18 | ± | 7.1 | (5) |
EOP9(%) | 0.9 | ± | 0.2 | (5) | 0.7 | ± | 0.2 | (5) | 0.8 | ± | 0.4 | (5) | 0.8 | ± | 0.3 | (5) |
BAP10(%) | 0.1 | ± | 0 | (5) | 0.1 | ± | 0.1 | (5) | 0 | ± | 0.1 | (5) | 0 | ± | 0 | (5) |
LYP11(%) | 81.1 | ± | 4.4 | (5) | 82.1 | ± | 4.2 | (5) | 83.9 | ± | 4 | (5) | 78.4 | ± | 7.3 | (5) |
MOP12(%) | 1.9 | ± | 0.5 | (5) | 1.4 | ± | 0.4 | (5) | 1.8 | ± | 1.1 | (5) | 2 | ± | 0.3 | (5) |
LUP13(%) | 0.5 | ± | 0.2 | (5) | 0.7 | ± | 0.3 | (5) | 0.8 | ± | 0.5 | (5) | 0.7 | ± | 0.2 | (5) |
RBC14(M/μL) | 7.89 | ± | 0.45 | (5) | 7.82 | ± | 0.83 | (5) | 7.65 | ± | 0.49 | (5) | 7.55 | ± | 0.55 | (5) |
Hb15(g/dL) | 15.5 | ± | 0.8 | (5) | 13.3 | ± | 2.5 | (5) | 14.7 | ± | 0.8 | (5) | 14.6 | ± | 0.6 | (5) |
RDW16(%) | 11.2 | ± | 0.4 | (5) | 11.3 | ± | 0.3 | (5) | 11.2 | ± | 0.4 | (5) | 11.8 | ± | 1 | (5) |
HCT17(%) | 46.8 | ± | 2.9 | (5) | 46.1 | ± | 3.6 | (5) | 45.1 | ± | 2.3 | (5) | 44.4 | ± | 2.7 | (5) |
MCV18(fL) | 59.3 | ± | 1.8 | (5) | 59.1 | ± | 3.6 | (5) | 59.1 | ± | 1.6 | (5) | 58.8 | ± | 2.3 | (5) |
MCH19(pg) | 19.6 | ± | 0.5 | (5) | 17.4 | ± | 4.3 | (5) | 19.2 | ± | 0.6 | (5) | 19.3 | ± | 1 | (5) |
MCHC20(g/dL) | 33.1 | ± | 0.7 | (5) | 29.3 | ± | 6.7 | (5) | 32.5 | ± | 0.3 | (5) | 32.8 | ± | 0.8 | (5) |
Reti21(%) | 2.6 | ± | 0.3 | (5) | 2.97 | ± | 0.57 | (5) | 2.65 | ± | 0.27 | (5) | 3.99 | ± | 2.72 | (5) |
PLT22(K/μL) | 1068 | ± | 110 | (5) | 1081 | ± | 136 | (5) | 1127 | ± | 193 | (5) | 1162 | ± | 111 | (5) |
MPV23(fL) | 6.9 | ± | 0.3 | (5) | 6.8 | ± | 0.8 | (5) | 7 | ± | 0.3 | (5) | 7.2 | ± | 0.1 | (5) |
Sex: Female | ||||||||||||||||
Test item | Group(mg/kg/day) | |||||||||||||||
G1(0) | G2(250) | G3(500) | G4(1000) | |||||||||||||
WBC1(K/μL) | 11.87 | ± | 3.21 | (5) | 7.09 | ± | 0.6 | (5) | 6.99 | ± | 1.99 | (5) | 8.08 | ± | 2 | (5) |
PMN2(K/μL) | 1.05 | ± | 0.17 | (5) | 0.72 | ± | 0.35 | (5) | 0.62 | ± | 0.15 | (5) | 1 | ± | 0.49 | (5) |
EO3(K/μL) | 0.1 | ± | 0.03 | (5) | 0.06 | ± | 0 | (5) | 0.07 | ± | 0.03 | (5) | 0.09 | ± | 0.03 | (5) |
BA4(K/μL) | 0.01 | ± | 0.01 | (5) | 0 | ± | 0.01 | (5) | 0 | ± | 0 | (5) | 0 | ± | 0.01 | (5) |
LY5(K/μL) | 10.4 | ± | 3.25 | (5) | 6.08* | ± | 0.74 | (5) | 6.05* | ± | 1.83 | (5) | 6.68* | ± | 1.87 | (5) |
MO6(K/μL) | 0.19 | ± | 0.04 | (5) | 0.16 | ± | 0.06 | (5) | 0.16 | ± | 0.04 | (5) | 0.19 | ± | 0.1 | (5) |
LUC7(K/μL) | 0.14 | ± | 0.04 | (5) | 0.06 | ± | 0.02 | (5) | 0.08 | ± | 0.03 | (5) | 0.11 | ± | 0.06 | (5) |
PMNP8(%) | 9.5 | ± | 3.3 | (5) | 10.3 | ± | 5 | (5) | 9.1 | ± | 1.6 | (5) | 12.7 | ± | 5.5 | (5) |
EOP9(%) | 0.9 | ± | 0.3 | (5) | 0.8 | ± | 0.1 | (5) | 1 | ± | 0.4 | (5) | 1.1 | ± | 0.2 | (5) |
BAP10(%) | 0 | ± | 0.1 | (5) | 0.1 | ± | 0 | (5) | 0 | ± | 0 | (5) | 0.1 | ± | 0.1 | (5) |
LYP11(%) | 86.8 | ± | 3.9 | (5) | 85.6 | ± | 5.8 | (5) | 86.4 | ± | 2.1 | (5) | 82.4 | ± | 6.7 | (5) |
MOP12(%) | 1.6 | ± | 0.5 | (5) | 2.4 | ± | 0.9 | (5) | 2.3 | ± | 0.3 | (5) | 2.4 | ± | 1 | (5) |
LUP13(%) | 1.1 | ± | 0.1 | (5) | 0.9 | ± | 0.2 | (5) | 1.1 | ± | 0.2 | (5) | 1.4 | ± | 0.4 | (5) |
RBC14(M/μL) | 7.66 | ± | 0.26 | (5) | 7.56 | ± | 0.23 | (5) | 7.72 | ± | 0.34 | (5) | 7.92 | ± | 0.37 | (5) |
Hb15(g/dL) | 14.4 | ± | 0.6 | (5) | 14.7 | ± | 0.4 | (5) | 14.7 | ± | 0.4 | (5) | 15.1 | ± | 0.6 | (5) |
RDW16(%) | 10.4 | ± | 0.2 | (5) | 10.4 | ± | 0.5 | (5) | 10.4 | ± | 0.4 | (5) | 10.4 | ± | 0.1 | (5) |
HCT17(%) | 42.2 | ± | 1.6 | (5) | 43.5 | ± | 1.1 | (5) | 43.1 | ± | 0.9 | (5) | 44.9 | ± | 2 | (5) |
MCV18(fL) | 55 | ± | 1.4 | (5) | 57.5* | ± | 0.5 | (5) | 55.9 | ± | 1.6 | (5) | 56.7 | ± | 1.1 | (5) |
MCH19(pg) | 18.7 | ± | 0.5 | (5) | 19.4 | ± | 0.3 | (5) | 19.1 | ± | 0.6 | (5) | 19.1 | ± | 0.5 | (5) |
MCHC20(g/dL) | 34 | ± | 0.2 | (5) | 33.8 | ± | 0.4 | (5) | 34.1 | ± | 0.4 | (5) | 33.7 | ± | 0.5 | (5) |
Reti21(%) | 2.07 | ± | 0.39 | (5) | 2.28 | ± | 0.41 | (5) | 2.13 | ± | 0.41 | (5) | 2.16 | ± | 0.37 | (5) |
PLT22(K/μL) | 1250 | ± | 99 | (5) | 1070 | ± | 107 | (5) | 1093 | ± | 125 | (5) | 1206 | ± | 179 | (5) |
MPV23(fL) | 6.4 | ± | 0.2 | (5) | 6.8 | ± | 0.3 | (5) | 6.7 | ± | 0.3 | (5) | 6.5 | ± | 0.2 | (5) |