Table 5 Comparison of common regulated canonical pathways in vitro and in vivo as analysed by IPA software

Glucocorticoid receptor signaling

1.28

1.60

0.58

1.13

2.19

2.42

2.31

2.12

2.37

2.79

Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis

1.85

1.85

0.31

2.79

1.04

1.62

2.60

1.81

4.62

–

NRF2-mediated Oxidative Stress Response

1.49

1.90

1.82

1.26

1.55

2.23

1.54

3.57

2.19

0.62

TNFR2 Signaling

1.55

0.98

1.19

4.64

0.30

1.54

1.08

1.75

3.83

1.00

Aryl Hydrocarbon Receptor Signaling

1.03

1.82

1.45

2.23

1.10

3.13

3.21

0.85

2.30

0.69

IL-17A Signaling in Fibroblast

1.20

1.52

2.30

3.57

0.28

1.19

1.68

1.64

3.62

0.36

Role of PKR in Interferon Induction and Antiviral Response

2.84

3.22

–

2.24

–

2.82

2.30

–

2.92

–

IL-17A Signaling in Gastric Cells

0.84

1.20

3.20

3.90

0.40

0.83

1.32

0.99

2.25

1.24

p38 MAPK Signaling

2.04

1.77

0.96

1.39

0.61

3.10

2.42

1.23

1.79

0.23

p53 Signaling

1.15

1.49

2.08

2.64

1.01

1.70

1.45

1.65

1.55

0.24

GADD45 Signaling

0.70

1.10

2.66

3.39

1.18

1.20

1.83

2.54

0.54

Il-6 Signaling

0.68

1.11

1.15

2.63

0.74

1.06

0.89

2.50

3.59

0.38

Aldosterone Signaling in Epithelial Cells

1.03

1.96

0.50

1.44

1.09

2.90

2.66

1.66

0.57

0.78

IL-10 Signaling

0.95

0.83

1.73

1.55

0.35

1.25

0.97

2.71

3.70

0.48

Unfolded Protein Response

1.47

1.70

1.68

1.51

0.88

1.45

1.91

1.20

2.03

0.20

PPAR Signaling

1.24

1.63

0.92

1.38

0.42

1.84

1.56

2.38

2.21

0.29