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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO2 particles: an in vivo and ex vivo study in mice

Fig. 3

Confocal and TEM localization of TiO2 particles in jejunal PP, 4 h after E171 oral administration. a-c Confocal imaging of TiO2 particles (green) (a) in the SED, (b) in a lymphoid follicle (FAE) or (c) in the FAE monolayer. The tissue auto-fluorescence in shown in red and the DAPI-labelled nucleus in blue. d, e TEM associated to EDX analysis. TiO2 particles are detected as endocytosed by two separate immune cells of the PP. Bars = 10 μm in confocal microscopy, and 1 μm or 200 nm in TEM

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Particle and Fibre Toxicology

ISSN: 1743-8977

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