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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation

Fig. 5

Claudin-5 turnover was postponed in ADAM17-knockdown bEnd.3 cells. a bEnd.3 stable clones with ADAM17-knockdown were built and the claudin-5 expression level was greatly elevated in these clones. b In bEnd.3 ADAM17-KD clones, the enzymatic kinetics of ADAM17 was not induced in responded to TiO2-NP treatment. c TiO2-NP-mediated claudin-5 degradation was strongly reduced in bEnd.3 ADAM17-KD cells. d TiO2-NP-mediated cell migration was also alleviated in bEnd.3 ADAM17-KD cells. *p < 0.05, **p < 0.01, ***p < 0.001, indicates statistically significant difference from the control treatment

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Particle and Fibre Toxicology

ISSN: 1743-8977

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