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Table 2 Lung burden of AuNPs, AgNPs, and AuNP+AgNP co-exposure (ng/lung)

From: Lung retention and particokinetics of silver and gold nanoparticles in rats following subacute inhalation co-exposure

AuNP

 

Single (ng of Au)A

Retention %

Co-exposure (ng of Au)B

Retention%

B/A

E-1 (4)

466 ± 34

313 ± 18

0.67 ± 0.04

PEO-1 (5)

8930 ± 742

100.0 ± 0

3607 ± 133**

100.0 ± 0.0

0.40 ± 0.01

PEO-7 (5)

8048 ± 1308

90.1 ± 11.6

3137 ± 220**

87.0 ± 6.1

0.39 ± 0.03

PEO-28 (5)

7010 ± 578

78.5 ± 6.5

2458 ± 224a,**

68.2 ± 6.2

0.35 ± 0.03

AgNP

 

Single (ng of Ag)C

Retention%

Co-exposure (ng of Ag)D

Retention %

D/C

E-1 (4)

47 ± 5

23 ± 1

0.49 ± 0.03

PEO-1 (5)

129 ± 15

100.00 ± 0.0

137 ± 6

100.0 ± 0.0

1.06 ± 0.05

PEO-7 (5)

90 ± 8

69.4 ± 5.8

72 ± 9a

52.8 ± 6.6

0.80 ± 0.10

PEO-28 (5)

58 ± 11a

45.0 ± 8.9

37 ± 5a,b

27.4 ± 3.8

0.64 ± 0.09

  1. Unit; mean ± S.E; (), number of animals per group; ng (in whole lung); E1, exposed for 1 day, PEO-1, post-exposure observation day 1; PEO-7 post-exposure observation day 7; PEO-28, post-exposure observation day 28; amount of deposition in whole lung = ng/g lung tissue analyzed by ICP-MS x whole lung weight and it was corrected the lung tissue spiked standard curve; further data details are included in Supplements 5, 6, 7 and 8; the clearance (%) was comparing PEO-1 for each a groups; B/A and D/C represent co-exposure/single exposure; Significant differences using ANOVA of multiple comparison; a) p < 0.05, comparing PEO-1; b) p < 0.05, comparing PEO-2; **p < 0.05 compared with single and co-exposure