|
AuNP
|
| |
Single (ng of Au)A
|
Retention %
|
Co-exposure (ng of Au)B
|
Retention%
|
B/A
|
|
E-1 (4)
|
466 ± 34
|
–
|
313 ± 18
|
–
|
0.67 ± 0.04
|
|
PEO-1 (5)
|
8930 ± 742
|
100.0 ± 0
|
3607 ± 133**
|
100.0 ± 0.0
|
0.40 ± 0.01
|
|
PEO-7 (5)
|
8048 ± 1308
|
90.1 ± 11.6
|
3137 ± 220**
|
87.0 ± 6.1
|
0.39 ± 0.03
|
|
PEO-28 (5)
|
7010 ± 578
|
78.5 ± 6.5
|
2458 ± 224a,**
|
68.2 ± 6.2
|
0.35 ± 0.03
|
|
AgNP
|
| |
Single (ng of Ag)C
|
Retention%
|
Co-exposure (ng of Ag)D
|
Retention %
|
D/C
|
|
E-1 (4)
|
47 ± 5
|
–
|
23 ± 1
|
–
|
0.49 ± 0.03
|
|
PEO-1 (5)
|
129 ± 15
|
100.00 ± 0.0
|
137 ± 6
|
100.0 ± 0.0
|
1.06 ± 0.05
|
|
PEO-7 (5)
|
90 ± 8
|
69.4 ± 5.8
|
72 ± 9a
|
52.8 ± 6.6
|
0.80 ± 0.10
|
|
PEO-28 (5)
|
58 ± 11a
|
45.0 ± 8.9
|
37 ± 5a,b
|
27.4 ± 3.8
|
0.64 ± 0.09
|
- Unit; mean ± S.E; (), number of animals per group; ng (in whole lung); E1, exposed for 1 day, PEO-1, post-exposure observation day 1; PEO-7 post-exposure observation day 7; PEO-28, post-exposure observation day 28; amount of deposition in whole lung = ng/g lung tissue analyzed by ICP-MS x whole lung weight and it was corrected the lung tissue spiked standard curve; further data details are included in Supplements 5, 6, 7 and 8; the clearance (%) was comparing PEO-1 for each a groups; B/A and D/C represent co-exposure/single exposure; Significant differences using ANOVA of multiple comparison; a) p < 0.05, comparing PEO-1; b) p < 0.05, comparing PEO-2; **p < 0.05 compared with single and co-exposure
