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Table 2 Lung burden of AuNPs, AgNPs, and AuNP+AgNP co-exposure (ng/lung)

From: Lung retention and particokinetics of silver and gold nanoparticles in rats following subacute inhalation co-exposure

AuNP
  Single (ng of Au)A Retention % Co-exposure (ng of Au)B Retention% B/A
E-1 (4) 466 ± 34 313 ± 18 0.67 ± 0.04
PEO-1 (5) 8930 ± 742 100.0 ± 0 3607 ± 133** 100.0 ± 0.0 0.40 ± 0.01
PEO-7 (5) 8048 ± 1308 90.1 ± 11.6 3137 ± 220** 87.0 ± 6.1 0.39 ± 0.03
PEO-28 (5) 7010 ± 578 78.5 ± 6.5 2458 ± 224a,** 68.2 ± 6.2 0.35 ± 0.03
AgNP
  Single (ng of Ag)C Retention% Co-exposure (ng of Ag)D Retention % D/C
E-1 (4) 47 ± 5 23 ± 1 0.49 ± 0.03
PEO-1 (5) 129 ± 15 100.00 ± 0.0 137 ± 6 100.0 ± 0.0 1.06 ± 0.05
PEO-7 (5) 90 ± 8 69.4 ± 5.8 72 ± 9a 52.8 ± 6.6 0.80 ± 0.10
PEO-28 (5) 58 ± 11a 45.0 ± 8.9 37 ± 5a,b 27.4 ± 3.8 0.64 ± 0.09
  1. Unit; mean ± S.E; (), number of animals per group; ng (in whole lung); E1, exposed for 1 day, PEO-1, post-exposure observation day 1; PEO-7 post-exposure observation day 7; PEO-28, post-exposure observation day 28; amount of deposition in whole lung = ng/g lung tissue analyzed by ICP-MS x whole lung weight and it was corrected the lung tissue spiked standard curve; further data details are included in Supplements 5, 6, 7 and 8; the clearance (%) was comparing PEO-1 for each a groups; B/A and D/C represent co-exposure/single exposure; Significant differences using ANOVA of multiple comparison; a) p < 0.05, comparing PEO-1; b) p < 0.05, comparing PEO-2; **p < 0.05 compared with single and co-exposure
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