AuNP |
| Single (ng of Au)A | Retention % | Co-exposure (ng of Au)B | Retention% | B/A |
E-1 (4) | 466 ± 34 | – | 313 ± 18 | – | 0.67 ± 0.04 |
PEO-1 (5) | 8930 ± 742 | 100.0 ± 0 | 3607 ± 133** | 100.0 ± 0.0 | 0.40 ± 0.01 |
PEO-7 (5) | 8048 ± 1308 | 90.1 ± 11.6 | 3137 ± 220** | 87.0 ± 6.1 | 0.39 ± 0.03 |
PEO-28 (5) | 7010 ± 578 | 78.5 ± 6.5 | 2458 ± 224a,** | 68.2 ± 6.2 | 0.35 ± 0.03 |
AgNP |
| Single (ng of Ag)C | Retention% | Co-exposure (ng of Ag)D | Retention % | D/C |
E-1 (4) | 47 ± 5 | – | 23 ± 1 | – | 0.49 ± 0.03 |
PEO-1 (5) | 129 ± 15 | 100.00 ± 0.0 | 137 ± 6 | 100.0 ± 0.0 | 1.06 ± 0.05 |
PEO-7 (5) | 90 ± 8 | 69.4 ± 5.8 | 72 ± 9a | 52.8 ± 6.6 | 0.80 ± 0.10 |
PEO-28 (5) | 58 ± 11a | 45.0 ± 8.9 | 37 ± 5a,b | 27.4 ± 3.8 | 0.64 ± 0.09 |
- Unit; mean ± S.E; (), number of animals per group; ng (in whole lung); E1, exposed for 1 day, PEO-1, post-exposure observation day 1; PEO-7 post-exposure observation day 7; PEO-28, post-exposure observation day 28; amount of deposition in whole lung = ng/g lung tissue analyzed by ICP-MS x whole lung weight and it was corrected the lung tissue spiked standard curve; further data details are included in Supplements 5, 6, 7 and 8; the clearance (%) was comparing PEO-1 for each a groups; B/A and D/C represent co-exposure/single exposure; Significant differences using ANOVA of multiple comparison; a) p < 0.05, comparing PEO-1; b) p < 0.05, comparing PEO-2; **p < 0.05 compared with single and co-exposure