|
First order model
|
T1/2, daya
|
AuNPs
|
81.5
|
AuNPs when co-exposed with AgNPs
|
54.2
|
|
Two-phase model
|
Fast-clearance phase
|
Slow-clearance phase
|
|
T1/2, daysa
|
T1/2, daysa
|
AgNPs
|
3.1
|
48.5
|
AgNPs when co-exposed with AuNPs
|
2.2
|
28.4
|
- These data were analyzed using a two-phase model (fast and slow); Ag showed a two-phase model, whereas Au showed first order kinetics
- The AuNPs and co-exposed AuNPs were analyzed based on a first order model using the equation [M(t)=P1exp(−λ1t)]
- The AgNPs and co-exposed AgNPs were analyzed based on a two-phase clearance (fast and slow) using the equation [M(t)=P1exp(−λ1t)+P2exp(−λ2t)], a) half-time time; T1/2 = ln(2) / λ (d1 and d2)