Lung retention and particokinetics of silver and gold nanoparticles in rats following subacute inhalation co-exposure

Table 3 Retention kinetics of AuNPs, AgNPs, and AuNP+AgNP co-exposure in lungs

	First order model
	T_1/2, day^a
AuNPs	81.5
AuNPs when co-exposed with AgNPs	54.2
	Two-phase model
	Fast-clearance phase	Slow-clearance phase
	T_1/2, days^a	T_1/2, days^a
AgNPs	3.1	48.5
AgNPs when co-exposed with AuNPs	2.2	28.4

These data were analyzed using a two-phase model (fast and slow); Ag showed a two-phase model, whereas Au showed first order kinetics
The AuNPs and co-exposed AuNPs were analyzed based on a first order model using the equation [M(t)=P₁exp(−λ₁t)]
The AgNPs and co-exposed AgNPs were analyzed based on a two-phase clearance (fast and slow) using the equation [M(t)=P1exp(−λ1t)+P2exp(−λ2t)], a) half-time time; T1/2 = ln(2) / λ (d₁ and d₂)

ISSN: 1743-8977