Table 5 Notable changes of biological parameters in mice after treatment with TiO2 and LPS
Group | 1 month | 3 months | 6 months |
|---|---|---|---|
L | Duodenal villi height/ crypt depth ratio ↑ Ileal villi height/ crypt depth ratio ↓ Ileal IL-1β ↓ | Duodenal villi height/ crypt depth ratio ↓ | Duodenal villi height/ crypt depth ratio ↓ Serum DAO ↓ Serum TNF-α ↑ |
NP | Duodenal villi height/ crypt depth ratio ↑ Ileal villi height/ crypt depth ratio ↓ Ileal Occludin ↑ | Ileal villi height/ crypt depth ratio ↑ | Food intake ↓ Serum IL-1β ↓ |
NP+L | Jejunal villi height/ crypt depth ratio ↑ Ileal ZO-1 ↑ | Jejunal villi height/ crypt depth ratio ↑ Serum DAO ↓ | Serum DAO ↓ Ileal IL-1β ↓ |
MP | Duodenal villi height/ crypt depth ratio ↑ Jejunal villi height/ crypt depth ratio ↑ Ileal ZO-1 ↑ | Jejunal villi height/ crypt depth ratio ↑ Ileal villi height/ crypt depth ratio ↑ Serum IL-1β ↓ | Ileal microvilli ↓, Blood Ti ↑ Serum IL-6 ↓ |
MP+L | Ileal villi height/ crypt depth ratio ↓ Ileal ZO-1 ↑ | Serum LPS ↓, Serum DAO ↓ | Ileal ZO-1 ↑ |