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Fig. 8 | Particle and Fibre Toxicology

Fig. 8

From: Respirable stone particles differ in their ability to induce cytotoxicity and pro-inflammatory responses in cell models of the human airways

Fig. 8

MCC950 induces a concentration-dependent decrease in stone particle-induced CXCL8 release in THP-1 macrophages. THP-1 macrophages were exposed to 0–0.1 μM MCC950 and incubated for 30 min before adding 200 μg/mL quartzite (a), anorthosite (b), rhomb porphyry (c), dacite (d), quartz diorite (e) and hornfels (f), and incubating the cells for 24 h. The level of CXCL8 in the cell culture supernatant was detected by ELISA. Results are presented as mean ± SD (n = 4) and are normalized to the mean response of each experiment. Statistical significance is based on a two-way ANOVA followed by Dunnet’s and Sidak post-tests. * Statistically significant difference from the respective control. # Statistically significant difference between exposure groups

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Particle and Fibre Toxicology

ISSN: 1743-8977

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