Fig. 6

Heat map for in vitro-in vivo comparison of genotoxicity potential. Low medium and high dose were different between A549, THP-1a cells and in mice, respectively. The stars represents significantly different DNA damage with respect to control within each NM toxicity test. A Heatmap for carbon black (P90) and NRCWE-006, which included BAL cells. B Heatmap for NM-400 (NRCWE-026 in vivo) and NM-401, which included lung tissue. C Heatmap for NRCWE-040, NRCWE-041, NRCWE-042, and NM-403, which included both BAL cells and lung tissue. D Scale of genotoxicity; a material is defined as genotoxic when the effects are ≥2SD higher than their respective control groups. E Summary table of correlation results. *, ** and *** designate P-values of < 0.05, < 0.01 and < 0.001, respectively in a 2-way ANOVA (see statistics for details)