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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Pulmonary delivery of the broad-spectrum matrix metalloproteinase inhibitor marimastat diminishes multiwalled carbon nanotube-induced circulating bioactivity without reducing pulmonary inflammation

Fig. 4

MWCNT-mediated pulmonary inflammatory activation. Bronchoalveolar lavage fluid (BALF) inflammatory cytokine profile assessed via Meso Scale Discovery multiplex cytokine assay. MWCNT-exposure increased BALF cytokine protein expression in a dose-dependent manner which was not significantly altered by MMP blockade. a IL-1β cytokine protein expression. b IL-2 cytokine protein expression. c IL-4 cytokine protein expression. d IL-5 cytokine protein expression. e IL-6 cytokine protein expression. f IL-10 cytokine protein expression. g IL12p70 cytokine protein expression. h IFN-γ cytokine protein expression. i TNF-α cytokine protein expression. j KC-Gro/CXCL1/GROα chemokine protein expression. p values based on 2-way ANOVA presented for each figure. N = 4–5 per group. Data presented are means ± SEM

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Particle and Fibre Toxicology

ISSN: 1743-8977

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