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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Exposure to environmentally relevant concentrations of ambient fine particulate matter (PM2.5) depletes the ovarian follicle reserve and causes sex-dependent cardiovascular changes in apolipoprotein E null mice

Fig. 1

Effects of PM2.5 exposure on ovarian follicle numbers: 3-month old female mice were exposed to concentrated ambient PM2.5 or filtered air 4 h per day, 5 days per week for 12 weeks and were euthanized 24 h after the last exposure day for enumeration of ovarian follicles as described in Methods. Graphs show the means ± SEM number of follicles per ovary. A Healthy primordial and primary follicle numbers were significantly decreased in PM2.5 exposed mice compared to air controls. B Healthy, but not atretic, secondary follicle numbers were significantly decreased in PM2.5 exposed mice compared to air controls. C Neither healthy, nor atretic antral follicle numbers were significantly changed in PM2.5 exposed mice compared to air controls. *P < 0.05 compared to air controls. N = 20/group

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Particle and Fibre Toxicology

ISSN: 1743-8977

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