Particle and Fibre Toxicology

Table 5 Intra-arterial and tail cuff systolic blood pressure (SBP) and diastolic blood pressure (DBP) in male and female Apoe-/- mice, 2017 cohort^#

From: Exposure to environmentally relevant concentrations of ambient fine particulate matter (PM_2.5) depletes the ovarian follicle reserve and causes sex-dependent cardiovascular changes in apolipoprotein E null mice

		Male			Female
		Air	PM_2.5	*P-value	Air	PM_2.5	*P-value
		Transmitter—Intra-arterial
Baseline	SBP	116.4 ± 1.0	119.1 ± 0.8	0.340	114.4 ± 2.8	117.3 ± 0.5	0.101
Baseline	DBP	96.7 ± 1.2	101.6 ± 1.0	0.003	97.6 ± 2.5	98.8 ± 0.7	0.271
Weeks 6–11	SBP	114.0 ± 1.4	117.2 ± 0.7	0.033	101.2 ± 1.7	122.7 ± 0.7	< 0.001
Weeks 6–11	DBP	95.9 ± 0.9	97.6 ± 0.5	0.089	84.3 ± 1.6	102.6 ± 0.9	< 0.001
		Transmitter—Tail Cuff
Baseline	SBP	123.8 ± 5.7	139.4 ± 9.8	0.203	143.7 ± 4.6	123.4 ± 8.5	0.070
	DBP	96.5 ± 2.7	111.2 ± 7.8	0.115	112.7 ± 3.0	96.6 ± 8.3	0.105
Weeks 6–11	SBP	129.0 ± 4.1	135.7 ± 4.3	0.264	145.0 ± 5.7	132.3 ± 8.5	0.099
	DBP	98.8 ± 4.1	105.7 ± 4.3	0.248	114.3 ± 5.0	103.8 ± 8.3	0.133
		Non-transmitter—Tail Cuff
Baseline	SBP	145.4 ± 4.9	139.3 ± 6.0	0.445	127.9 ± 4.2	135.5 ± 4.4	0.226
	DBP	116.6 ± 4.3	103.2 ± 4.2	0.038	100.5 ± 4.4	105.5 ± 4.0	0.404
Weeks 6–11	SBP	140.1 ± 6.5	139.8 ± 6.2	0.942	139.2 ± 9.3	140.1 ± 4.4	0.817
	DBP	109.3 ± 5.4	109.1 ± 5.2	0.950	112.2 ± 7.5	111.2 ± 4.0	0.769

N = 10/experimental group, Non-transmitter; N = 4–5/experimental group, Transmitter
*P-values are for PM_2.5 versus Air of same sex and BP measurement method, t-test
^#Blood pressures are in mmHg

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