Particle and Fibre Toxicology

Table 6 Intra-arterial and tail cuff systolic blood pressure (SBP) and diastolic blood pressure (DBP) in OVAX and SHAM female ApoE-/- mice, 2018 cohort

From: Exposure to environmentally relevant concentrations of ambient fine particulate matter (PM_2.5) depletes the ovarian follicle reserve and causes sex-dependent cardiovascular changes in apolipoprotein E null mice

			OVAX			SHAM
			Air	PM_2.5	P-value	Air	PM_2.5	P-value
			Transmitter—Intra-arterial
Baseline	SBP	mmHg	122.8 ± 1.3	121.3 ± 1.5	0.454	123.5 ± 0.9	127.4 ± 1.3	0.020
Baseline	DBP	mmHg	99.3 ± 2.2	95.6 ± 1.4	0.139	99.2 ± 1.2	99.6 ± 1.0	0.778
Weeks 6–11	SBP	mmHg	123.6 ± 0.6	123.7 ± 0.6	0.931	129.8 ± 0.5	122.4 ± 1.1	< 0.001
Weeks 6–11	DBP	mmHg	102.0 ± 1.0	100.7 ± 0.6	0.242	101.3 ± 0.5	96.6 ± 0.9	< 0.001
			Non-transmitter—Tail Cuff
Baseline	SBP	mmHg	125.2 ± 3.8	131.7 ± 4.8	0.302	136.9 ± 5.4	133.6 ± 3.2	0.609
	DBP	mmHg	103.1 ± 3.1	107.9 ± 2.9	0.274	109.3 ± 4.5	108.9 ± 3.0	0.946
Weeks 6–11	SBP	mmHg	134.8 ± 2.8	145.3 ± 3.4	0.018	140.4 ± 2.4	138.5 ± 2.8	0.602
	DBP	mmHg	111.1 ± 2.5	119.1 ± 3.2	0.054	113.2 ± 2.4	112.5 ± 2.4	0.851

P-values are for PM_2.5 versus Air of same group and BP measurement method, t-test
N = 10, Non-transmitter; N = 4–5, Transmitter

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