Fig. 2

Behaviour tasks performances of C57BL/6J and 5xFAD mice. Mice were exposed for 3 weeks (A–C) or 14 weeks (D–I) to SiO₂ [0.1%, 1%] or CeO₂ [0.1%, 1%] nanomaterials in food pellets ad libitum. Data represent mean ± SEM of the% alternation and distance moved (m) in the X-maze task (A, B, D, E), the % centre duration and distance (m) moved in the open field task (G, H) and the time to reach the platform (s) of the balance beam test (I) for C57BL/6J mice (open squares) and 5xFAD mice (solid squares). String suspension task score data are indicated as scatterplots and median values are indicated as horizontal bars (C, F) for C57BL/6J mice (open triangles) and 5xFAD mice (solid diamonds). Statistical analysis was performed using ANOVA followed by Dunnett post-hoc evaluation for X-maze, string and balance beam tests. Results of the string suspension task were evaluated by the Kruskal–Wallis test followed by Dunn-Bonferroni post hoc evaluation; *p < 0.01 versus corresponding C57BL/6J or 5xFAD mice exposed to control feed pellets. Number of animals per group: 3 weeks C67BL/6J control (n = 6); SiO₂ 0.1% (n = 6); SiO₂ 1% (n = 7); CeO₂ 0.1% (n = 6). CeO₂ 1% (n = 6); 5xFAD control (n = 10); SiO₂ 0.1% (n = 10); SiO₂ 1% (n = 9); CeO₂ 0.1% (n = 10). CeO₂ 1% (n = 10); 14 weeks C67BL/6J control (n = 5); SiO₂ 0.1% (n = 6); SiO₂ 1% (n = 6); CeO₂ 0.1% (n = 6). CeO₂ 1% (n = 6); 5xFAD control (n = 11); SiO₂ 0.1% (n = 9); SiO₂ 1% (n = 10); CeO₂ 0.1% (n = 10). CeO₂ 1% (n = 10)