Effects of subchronic dietary exposure to the engineered nanomaterials SiO2 and CeO2 in C57BL/6J and 5xFAD Alzheimer model mice

Sofranko, Adriana; Wahle, Tina; Kolling, Julia; Heusinkveld, Harm J.; Stahlmecke, Burkhard; Rosenbruch, Martin; Albrecht, Catrin; Schins, Roel P. F.

doi:10.1186/s12989-022-00461-2

Table 1 Body and organ weights

From: Effects of subchronic dietary exposure to the engineered nanomaterials SiO₂ and CeO₂ in C57BL/6J and 5xFAD Alzheimer model mice

	Control		SiO₂ [0.1%]		SiO₂ [1%]		CeO₂ [0.1%]		CeO₂ [1%]
	C57BL/6J	5xFAD	C57BL/6J	5xFAD	C57BL/6J	5xFAD	C57BL/6J	5xFAD	C57BL/6J	5xFAD
A
Body weight, sacrifice (g)	20.17 ± 1.32	19.15 ± 0.82	19.12 ± 1.03	18.78 ± 0.92	19.23 ± 0.67	18.58 ± 0.92	19.65 ± 1.51	19.23 ± 1.04	19.15 ± 0.91	19.20 ± 0.78
Body weight gain (g)^a	2.47 ± 0.66	2.21 ± 0.33	1.80 ± 0.47	2.03 ± 0.61	1.83 ± 0.35	1.79 ± 1.03	2.17 ± 0.52	2.46 ± 1.17	2.15 ± 0.42	2.38 ± 0.47
Liver/body weight (mg g⁻¹)	45.28 ± 8.89	44.71 ± 5.55	43.52 ± 4.78	47.36 ± 5.57	42.64 ± 6.70	45.27 ± 8.54	47.04 ± 2.06	44.50 ± 4.74	44.96 ± 3.04	44.08 ± 7.27
Spleen/body weight (mg g⁻¹)	4.07 ± 0.31	3.80 ± 0.40	4.31 ± 0.76	4.10 ± 0.51	3.66 ± 0.47	4.23 ± 0.65	3.92 ± 0.66	3.92 ± 0.38	3.82 ± 0.29	3.89 ± 0.69
Kidney/body weight (mg g⁻¹)	10.20 ± 3.01	8.99 ± 3.61	10.18 ± 3.22	8.60 ± 3.25	9.92 ± 2.62	8.60 ± 3.41	10.74 ± 3.82	8.60 ± 2.98	9.64 ± 2.83	9.22 ± 3.21
Colon/body weight (mg g⁻¹)	8.19 ± 0.81	8.39 ± 1.37	8.19 ± 1.03	8.15 ± 1.09	8.17 ± 0.91	8.69 ± 0.85	8.55 ± 0.78	8.91 ± 0.78	8.03 ± 1.23	8.79 ± 1.22
Small int./body weight (mg g⁻¹)	42.51 ± 6.00	42.38 ± 7.08	40.47 ± 6.60	46.40 ± 5.41	40.96 ± 7.20	40.89 ± 13.61	39.84 ± 7.16	44.34 ± 5.74	45.72 ± 1.55	46.69 ± 3.28
B
Body weight, sacrifice (g)	21.68 ± 1.36	22.56 ± 1.25	23.72 ± 1.53	22.32 ± 2.24	22.33 ± 1.39	21.60 ± 1.03	22.47 ± 1.05	22.92 ± 1.65	25.20* ± 2.14	21.92 ± 0.26
Body weight gain (g)^a	3.98 ± 0.80	4.96 ± 0.60	5.10 ± 1.19	4.72 ± 1.07	4.28 ± 1.28	3.88 ± 0.67	3.73 ± 0.69	5.45 ± 1.64	6.72* ± 1.59	4.47 ± 0.77
Liver/body weight (mg g⁻¹)	42.59 ± 2.92	42.20 ± 4.57	39.62 ± 2.99	42.97 ± 1.97	43.67 ± 3.97	43.47 ± 1.61	42.37 ± 5.91	43.80 ± 2.96	36.77 ± 3.20	43.83 ± 3.51
Spleen/body weight (mg g⁻¹)	3.61 ± 0.36	3.55 ± 0.27	3.46 ± 0.27	3.60 ± 0.45	4.09 ± 1.02	3.48 ± 0.44	3.44 ± 0.41	3.61 ± 0.52	3.05 ± 0.34	3.50 ± 0.39
Kidney/body weight (mg g⁻¹)	6.03 ± 0.47	6.07 ± 0.39	5.68 ± 0.64	5.99 ± 0.32	6.15 ± 0.88	6.26 ± 0.53	6.26 ± 0.42	6.07 ± 0.39	5.61 ± 0.73	5.52 ± 1.96
Colon/body weight (mg g⁻¹)	8.08 ± 1.05	8.25 ± 0.84	7.77 ± 0.86	8.36 ± 0.67	9.13 ± 1.09	8.38 ± 0.58	8.68 ± 1.01	8.50 ± 0.46	7.55 ± 0.41	8.84 ± 0.83
Small int./body weight (mg g⁻¹)	36.80 ± 1.84	36.39 ± 3.50	36.83 ± 5.11	38.14 ± 3.78	35.88 ± 3.88	36.89 ± 3.59	37.05 ± 4.18	36.19 ± 4.20	31.29 ± 2.33	36.65 ± 3.92

Data represent mean ± SD of C57BL/6J and 5xFAD mice body and organ weights after 3 weeks (A) or 14 weeks (B) exposure to CeO₂ or SiO₂ [0.1% or 1%] in feed pellets ad libitum versus the body and organ weights of the corresponding mice that received control feed pellets. Statistical analysis was performed using ANOVA with Dunnett evaluation;
*Versus control feed pellets exposed C57BL/6J mice, p < 0.01
^aBody weight gain at time interval between exposure start and sacrifice

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