Fig. 7

Double staining of rat lungs for α-smooth muscle actin (αSMA; green), and vascular endothelial growth factor receptor 3 (VEGFR3; a lymphatic marker, brown in the apical membrane) with counterstaining of hematoxylin. Representative loupe photograph and their magnified images of extrapulmonary region, bronchovascular bundle (BVB), alveolar region and CWAAP-A-induced lesion are shown for each control (a), immediately after 13-week exposure (b) and during the 13 week recovery period (c)