Table 2 Summary of modifications in membrane composition in HepaRG cells exposed to NM-103 and NM-104 at a concentration of 3.13 µg/cm2 for 1 week, 2 weeks and for 1 week with a 1-week recovery period
From: Chronic effects of two rutile TiO2 nanomaterials in human intestinal and hepatic cell lines
HepaRG | NM103 | NM104 | |||
|---|---|---|---|---|---|
Ion m/z | Putative identity | Effect | Recoverable | Effect | Recoverable |
100 | Arginine | ↑ | ✗ | ↑ | ✗ |
322 | Sphingosine-1-phosphate (d14:2) | ↓ | ✗ | ↓ | ✗ |
352 | Sphingosine-1-phosphate (d16:1) | ↓ | ✗ | ↓ | ✗ |
548 | Lyso-phosphatidylcholine (C20:2) | ↓ | ✗ | ↓ | ✗ |
528 | Lyso-phosphatidylethanolamine (C22:3) | ↓ | ✓ | ↓ | ✓ |
540 | Lyso-phosphatidylcholine (C20:6) | ↓ | ✓ | ↓ | ✓ |
544 | Lyso-phosphatidylcholine (C20:4) | ↓ | ✓ | ↓ | ✓ |
559 | Diacyl glycerol (C32:5) | ↓ | ✓ | ↓ | ✓ |