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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Aryl hydrocarbon receptor activation-mediated vascular toxicity of ambient fine particulate matter: contribution of polycyclic aromatic hydrocarbons and osteopontin as a biomarker

Fig. 5

PM2.5-bound PAHs induced cell migration and OPN and IL-6 expression in VSMCs. VSMCs were treated with DMSO and 0.3μg/mL BaA, BaP, BbF, BeP, BkF, chrysene, or DahA for 48 h. The following parameters were determined: A migration abilities of VSMCs; B correlation between the AC50 of AhR activation in the ToxCast and PM2.5-induced migration abilities in VSMCs; C correlation between the AC10 of AhR activation in the ToxCast and PM2.5-induced migration abilities in VSMCs; D OPN protein levels in the media; E CYP1A1 relative mRNA levels; F CYP1B1 relative mRNA levels; and G IL-6 protein levels in the media. The results are presented as mean ± SD for three independent experiments with 2–4 replicates in each experiment.*p < 0.05 compared with the DMSO-treated cells (n = 3, one-way ANOVA). Control: DMSO treatment as control

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Particle and Fibre Toxicology

ISSN: 1743-8977

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