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Table 1 Ambient concentrations of selected PAHs in PM2.5 and their BaP-TEQs and contributions of PAHs to BaP-TEQs based on relative potencies (REPs) determined in AhR-CALUX and AZ-AhR assays

From: Aryl hydrocarbon receptor activation-mediated vascular toxicity of ambient fine particulate matter: contribution of polycyclic aromatic hydrocarbons and osteopontin as a biomarker

Compound Abbreviation PAH concentrations in PM2.5 (ng/m3) ToxCast human HepG2-based AhR-CALUX cells Human HepG2-AZ-AhR cells
REPa BaP-TEQs (ng/m3)b Contribution of PAHs to total BaP-TEQ (%) REPc BaP-TEQs (ng/m3)b Contribution of PAHs to total BaP-TEQ (%)
Benz(a)anthracene BaA 0.07 ± 0.02 0.29 0.02 ± 0.01 0.08 ± 0.03 0.60 0.04 ± 0.01 0.63 ± 0.19
Chrysene CHR 0.19 ± 0.04 0.34 0.07 ± 0.01 0.24 ± 0.08 1.50 0.29 ± 0.06 4.09 ± 1.21
Benzo(b)fluoranthene BbF 0.30 ± 0.08 5.44 1.63 ± 0.42 5.83 ± 2.00 4.00 1.19 ± 0.32 16.61 ± 4.85
Benzo(k)fluoranthene BkF 0.12 ± 0.03 213.39 25.81 ± 7.41 86.52 ± 3.87 43.20 5.23 ± 1.52 69.61 ± 6.87
Benz(e)pyrene BeP 0.22 ± 0.06 2.02 0.44 ± 0.13 1.57 ± 0.60 NA – –
Benzo(a)pyrene BaP 0.13 ± 0.03 1.00 0.13 ± 0.03 0.47 ± 0.17 1.00 0.13 ± 0.03 1.85 ± 0.59
Dibenz(a,h)anthracene D(a,h)A 0.03 ± 0.01 49.45 1.49 ± 0.51 5.29 ± 2.16 17.20 0.52 ± 0.18 7.22 ± 2.71
Total   1.07 ± 0.25 – 29.59 ± 7.45 100 – 7.41 ± 1.57 100
  1. Values are presented as mean ± standard deviation. NA not available
  2. aCalculated by dividing AC50 of BaP (the reference compound) by the AC50 of other PAHs
  3. ToxCast’s AC50 were provided in the Additional file 1: Table 2
  4. bCalculated using Eq. (1)
  5. cAdopted from Vondráček et al. (2017)
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Particle and Fibre Toxicology

ISSN: 1743-8977

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