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Fig. 2 | Particle and Fibre Toxicology

Fig. 2

From: Landscape of lipidomic metabolites in gut-liver axis of Sprague–Dawley rats after oral exposure to titanium dioxide nanoparticles

Fig. 2

Effect of TiO2 nanoparticles on lipid metabolism in gut of rats. A Multivariate analysis of untargeted metabolomic data by OPLS-DA model showed the significant overall difference in metabolites of feces between the TiO2 NPs treated group (50 mg/kg) and the control group. B Volcano plot was mapped to distinguish differential metabolites between different groups, taking VIP > 1 and p < 0.05 as the demarcation standard. C The concentrations of well-matched differential lipophilic metabolite in feces were shown in heatmap and analyzed by hierarchical clustering. D KEGG pathway analysis showed that oral exposure to TiO2 NPs induced significant changes of Glycerophospholipid metabolism pathway in feces of rats

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Particle and Fibre Toxicology

ISSN: 1743-8977

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