Skip to main content
Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in rats

Fig. 5

Heat map plot of the normalized sensitivity coefficient (NSC) for comparative sensitivity analyses for 5 nm AuNPs at 24 h and 672 h following: a oral administration (Oral), b intravenous injection (IV), c intratracheal instillation (IT), and d 23 nm AuNPs following inhalation administration (IH). The plot identifies highly influential parameters with darker colors (red or blue) to the 24 h and 672 h dose metrics. Values of NSCs are provided in Additional file 1: Tables S8–S11. AUCB, AUCLu, AUCGI, AUCS, AUCL, AUCK and AUCRt represent area-under-the-concentration curve of gold nanoparticles (AuNPs) in blood, lungs, gastrointestinal (GI) tract, spleen, liver, and kidneys and remaining tissues, respectively

Back to article page

Particle and Fibre Toxicology

ISSN: 1743-8977

Contact us