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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in rats

Fig. 6

Model evaluation results with pharmacokinetic data in rats following intravenous injection (IV) of AuNPs [47, 48] with different surface coatings, including: a citrate (the same coating as our calibration data), b 11-mercaptoundecanoic acid (11-MUA), c Cys-Ala-Leu-Asn-Asn (CALNN), d Cys-Ala-Leu-Asn-Asp (CALND), e Cys-Ala-Leu-Asn-Ser (CALNS) and f citrate. The red and light green bars represent the observed and predicted values, respectively. The pharmacokinetic data of ae and f were collected at 24 h and 28 days after administration of AuNPs from Morais et al. [47] and Fraga et al. [48], respectively. The physicochemical characteristics of AuNPs are summarized in Table S14 in the Additional file 1. *Indicates that the difference between the simulated mean concentration and the observed mean concentration was more than twofold

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