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Table 2 Top 20 most abundant proteins for SHDS-treated and untreated FNPs

From: Changes of physico-chemical properties of nano-biomaterials by digestion fluids affect the physiological properties of epithelial intestinal cells and barrier models

  FNP SHDS + DMEM 10% FBS FNP DMEM 10% FBS
  LFQ ± SEM (x1E08) Protein Name Protein ID MW (kDa) LFQ ± SEM (x1E08) Protein Name Protein ID MW (kDa)
1 12.4 ± 3.4 Bovine Alpha-2-HS-glycoprotein* P12763 38.4 8.11 ± 1.6 Bovine Haemoglobin foetal subunit beta* P02081 15.9
2 12.3 ± 1.8 Bovine Alpha-1-antiproteinase* P34955 46.1 4.81 ± 0.19 Bovine Alpha-1-antiproteinase* P34955 46.1
3 10.0 ± 0.90 Pig Peptidase S1 domain-containing protein** I3LHI7 27.7 3.99 ± 0.050 Bovine Alpha-2-HS-glycoprotein* P12763 38.4
4 7.96 ± 0.32 Bovine Albumin* P02769 69.3 3.27 ± 0.34 Bovine Albumin* P02769 69.3
5 6.84 ± 1.1 Bovine Haemoglobin foetal subunit beta* P02081 15.9 3.22 ± 0.70 Bovine Haemoglobin subunit alpha* P01966 15.2
6 4.03 ± 0.60 Bovine Apolipoprotein A-I* P15497 30.3 2.67 ± 0.35 Bovine Apolipoprotein A-I* P15497 30.3
7 3.42 ± 0.76 Bovine Histone H2A type 2-C A1A4R1 14 2.45 ± 0.11 Bovine Inter-alpha-trypsin inhibitor heavy chain H2* A0A3Q1LK49 96.8
8 2.45 ± 0.24 Bovine Haemoglobin subunit alpha* P01966 15.2 2.35 ± 0.35 Bovine Angiotensinogen* P01017 51.4
9 2.43 ± 0.35 Pig Triacylglycerol lipase** F1S4T9 51.6 2.04 ± 0.18 Bovine Alpha-fetoprotein* Q3SZ57 68.6
10 2.42 ± 0.35 Pig HATPase_c domain-containing protein** A0A287A9T4 83 1.90 ± 0.16 Bovine Apolipoprotein A-II* P81644 11.2
11 2.32 ± 0.57 Bovine Serpin family G member 1 E1BMJ0 51.8 1.88 ± 0.14 Bovine Inter-alpha-trypsin inhibitor heavy chain H4 F1MMD7 101.5
12 2.26 ± 0.42 Pig Carboxypeptidase A1** P09954 47.2 1.87 ± 0.10 Bovine Alpha-1-microglobulin F1MMK9 53
13 2.02 ± 0.80 Bovine Angiotensinogen* P01017 51.4 1.80 ± 0.17 Bovine Beta-2-glycoprotein 1* P17690 38.3
14 2.00 ± 0.13 Bovine Alpha-fetoprotein* Q3SZ57 68.6 1.54 ± 0.090 Bovine Alpha-2-macroglobulin Q7SIH1 167.6
15 1.61 ± 0.85 Bovine Histone H2A F2Z4G5 14.1 1.52 ± 0.15 Bovine Fetuin-B Q58D62 42.7
16 1.58 ± 0.10 Bovine Beta-2-glycoprotein 1* P17690 38.3 1.46 ± 0.24 Bovine Vitronectin* Q3ZBS7 53.6
17 1.58 ± 0.10 Bovine Inter-alpha-trypsin inhibitor heavy chain H2* A0A3Q1LK49 96.8 1.46 ± 0.037 Bovine Complement C3 Q2UVX4 187.3
18 1.39 ± 0.16 Bovine Apolipoprotein A-II* P81644 11.2 1.39 ± 0.12 Bovine Alpha-1B-glycoprotein Q2KJF1 53.6
19 1.30 ± 0.19 Pig Peptidase S1 domain-containing protein** I3LJ52 26.9 1.28 ± 0.11 Bovine Inter-alpha-trypsin inhibitor heavy chain H3 P56652 99.6
20 1.14 ± 1.7 Bovine Vitronectin* Q3ZBS7 53.6 1.28 ± 0.11 Bovine Complement factor B P81187 85.4
  1. *Common proteins; **proteins from SHDS. LFQ was calculated with Perseus (n = 3). SEM refer to the standard error of the mean for n = 3