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Table 2 Incidence and number of pulmonary dust foci

From: Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

Concentration (mg/m3)

No. of rats

Pulmonary dust foci

Incidence (%)

Number (average ± SD)

 

No./slide

No./cm2 lung

Male

0

10

0 (0)

0

0

6.3

10

0 (0)

0

0

12.5

10

1 (10)

0.10 ± 0.32

0.07 ± 0.21

25

10

5 (50) $$

2.10 ± 2.60

1.12 ± 1.36

50

10

10 (100)$$$

76.40 ± 18.37***

47.85 ± 15.65***

Female

0

10

0 (0)

0

0

6.3

10

2 (20)

0.20 ± 0.42

0.17 ± 0.36

12.5

10

4 (40)$

0.40 ± 0.52

0.33 ± 0.42

25

10

9 (90)$$$

7.80 ± 4.44

5.37 ± 3.23

50

10

10 (100)0

99.00 ± 25.43***,###

70.89 ± 21.03***,###

  1. Significant difference: $, p < 0.05; $$, p < 0.01; $$$, p < 0.001 by Chi square test compared with the respective controls
  2. ***, p < 0.001 compared with the respective controls or ###, p < 0.001 compared with the male 50 mg/m3 group by two-way ANOVA with Tukey's multiple comparison test
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Particle and Fibre Toxicology

ISSN: 1743-8977

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