Table 2 The panel of silica NFs used for the case study to assess the performance of the GRACIOUS oral IATA to support grouping of NFs
|  | Crystallinity | Synthesis method | Surface Treatments | Shape | Specific surface area (BET, m2/g) | Constituent particle size (nm, average ± SD) by Manufacturers | Constituent particle size (nm, average ± SD) experimentally measured |
|---|---|---|---|---|---|---|---|
NM-200 | Amorphous | Wet (precipitation) | None | Spheroidal | 189 | 14 ± 7 | 20.7 ± 6.2 |
NM-203 | Amorphous | Thermal (pyrogenesis) | None | Spheroidal | 203 | 13 ± 6 | 13.3 ± 4.1 |
Silica-Std | Amorphous | Wet (colloidal) | None | Spheroidal | 209 | 10 | 10.0 ± 2.1 |
Silica-Silane | Amorphous | Wet (colloidal) | Surface modified with glycerol-propyl moieties from alkyl-tri-alkoxysilanes | Spheroidal | 216 | 10 | 12.1 ± 2.4 |
Silica-Al | Amorphous | Wet (colloidal) | Surface modification with Na-aluminate | Spheroidal | 175 | 11 | 13.3 ± 4.1 |
MCM-60 | Mesoporous | Wet (colloidal) | None | Spheroidal | 1647 | 60 ± 10 | 69.5 ± 12.8 |
MCM-170 | Mesoporous | Wet (colloidal) | None | Spheroidal | 1111 | 165 ± 21 | 151.2 ± 71.0 |