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Table 4 Summary of the groups generated by the similarity assessment on the HepG2/C3A hazard in vitro assays related to the H-O-G2 hypothesis

From: Grouping of orally ingested silica nanomaterials via use of an integrated approach to testing and assessment to streamline risk assessment

Viability grouping

IL-8 mRNA grouping

IL-8 Protein grouping

Group 1

Group 2

Group 1

Group 2

Group 1

Group 2

MCM-60

Silica-Silane

NM-200

NM-203

Silica-Std

Silica-Al

MCM-60

Silica-Silane

NM-200

NM-203

Silica-Al

Silica-Std

MCM-60

Silica-Silane

Silica-Std

Silica-Al

NM-200

NM-203