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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Establishing relationships between particle-induced in vitro and in vivo inflammation endpoints to better extrapolate between in vitro markers and in vivo fibrosis

Fig. 3

PMN influx following exposure to α-quartz. Data chosen for IVIVE is represented by the different methods of calculating extrapolated dose. Dose corresponding to retained lung burden values (red), or calculated using MPPD airway deposition (blue), and MPPD alveolar deposition (green). Best-fit IC50 and Hillslope values provided were calculated using nonlinear regression “Sigmoidal, 4PL, X is concentration” analysis in GraphPad. Data points given are mean ± SEM

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Particle and Fibre Toxicology

ISSN: 1743-8977

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