Table 2 Summary of the results from log–log regression analysis for α-quartz
Criterion of comparability | Cytokine/Chemokine | |||
|---|---|---|---|---|
IL-8 | IL-6 | IL-1β | TNF-α | |
Strength of dose-dependent response (overall associations) | 2/4 | 3/7 | 1/6 | 5/13 |
Concordance between all cells of the same phenotypes | No overlap | No overlap | No overlap | Overlap between RAW 246.7 cells of Balduzzi et al. [52] and J774A.1 cells of Boyles et al. [50] (P = .393) and Nattrass et al. [51] (P = .113) |
Concordance between specific cell lines | No overlap | No overlap | No overlap | No overlap |
In vivo/in vitro correlation | Statistically different to in vivo response (P < .05) | 1 study (Damby et al. [47]) not statistically different (P > .05) compared to in vivo response | Statistically different to in vivo response (P < .05) | Nattrass et al. [51] /Balduzzi et al. [52]: overlap with in vivo response (P > 0.205) |