Establishing relationships between particle-induced in vitro and in vivo inflammation endpoints to better extrapolate between in vitro markers and in vivo fibrosis

Table 5 Summary of the results from log–log regression analysis for nano-CeO₂

Criterion of comparability	Cytokines/Chemokines
Criterion of comparability	IL-8	IL-6	IL-1β	TNF- α
Strength of dose-dependent response (overall associations)	0/1	3/5	1/3	0/3
In vivo/in vitro correlation	N/A	Overall in vivo PMN influx overlaps with both Kim et al. [58] associations P = .922 and P = .704	No overlap P < .001	N/A

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