Table 1 Haematology of F344/DuCrlCrlj rats treated with titanium dioxide nanoparticles for 28 days

Male

No. of animals

5

5

5

5

RBC (× 10⁶/μl)

8.90 ± 0.59

8.91 ± 0.28

8.90 ± 0.47

9.03 ± 0.23

HGB (g/dL)

15.5 ± 0.9

15.4 ± 0.5

15.5 ± 0.7

15.5 ± 0.3

HCT (%)

45.2 ± 3.3

45.1 ± 1.8

45.3 ± 2.3

45.7 ± 0.8

MCV (fL)

50.7 ± 0.7

50.5 ± 0.4

50.9 ± 0.6

50.6 ± 0.4

MCH (pg)

17.5 ± 0.3

17.2 ± 0.2

17.4 ± 0.2

17.2 ± 0.2

MCHC (g/dL)

34.4 ± 0.6

34.1 ± 0.5

34.2 ± 0.3

34.0 ± 0.1

RET (%)

3.16 ± 0.40

3.03 ± 0.22

2.97 ± 0.21

3.01 ± 0.23

PLT (× 10³/μl)

512 ± 323

751 ± 67

730 ± 85

774 ± 25

WBC (× 10³/μl)

6.75 ± 1.23

4.73 ± 0.93*

5.89 ± 1.35

5.10 ± 0.82

Differential cell count

 NEUT (%)

19.7 ± 5.79

23.7 ± 4.52

28.6 ± 7.99

26.5 ± 2.27

 LYMPH (%)

75.8 ± 6.15

72.9 ± 4.62

66.8 ± 7.77

69.8 ± 2.78

 MONO (%)

2.78 ± 1.11

2.56 ± 0.52

3.30 ± 2.02

2.72 ± 0.54

 EO (%)

1.52 ± 1.11

0.72 ± 0.16

0.98 ± 0.50

0.76 ± 0.22

 BASO (%)

0.20 ± 0.07

0.12 ± 0.11

0.24 ± 0.11

0.26 ± 0.13

Female

No. of animals

5

5

5

5

RBC (× 10⁶/μl)

9.06 ± 0.24

9.05 ± 0.28

9.23 ± 0.34

9.17 ± 0.11

HGB (g/dL)

16.1 ± 0.3

16.1 ± 0.5

16.3 ± 0.6

16.1 ± 0.2

HCT (%)

46.8 ± 1.1

46.4 ± 1.8

47.4 ± 1.9

46.8 ± 0.7

MCV (fL)

51.6 ± 0.6

51.2 ± 0.5

51.3 ± 0.4

51.1 ± 0.5

MCH (pg)

17.8 ± 0.1

17.8 ± 0.1

17.7 ± 0.2

17.5 ± 0.1**

MCHC (g/dL)

34.4 ± 0.3

34.8 ± 0.3

34.4 ± 0.2

34.3 ± 0.3

RET (%)

2.52 ± 0.18

2.62 ± 0.26

2.58 ± 0.30

2.53 ± 0.45

PLT (× 10³/μl)

707 ± 48

670 ± 205

598 ± 265

740 ± 110

WBC (× 10³/μl)

4.35 ± 1.41

4.04 ± 1.20

4.18 ± 1.24

4.90 ± 2.20

Differential cell count

 NEUT (%)

17.6 ± 3.09

17.7 ± 4.88

16.9 ± 5.41

18.1 ± 6.58

 LYMPH (%)

77.4 ± 3.12

74.4 ± 12.15

78.1 ± 4.63

77.2 ± 7.04

 MONO (%)

3.24 ± 0.54

3.26 ± 0.89

3.24 ± 0.53

2.80 ± 0.59

 EO (%)

1.52 ± 0.51

4.34 ± 6.46

1.56 ± 1.15

1.64 ± 0.49

 BASO (%)

0.18 ± 0.11

0.36 ± 0.36

0.20 ± 0.12

0.30 ± 0.12