Table 3 Organ weights of F344/DuCrlCrlj rats treated with titanium dioxide nanoparticles for 28 days

Male

No. of animals

5

5

5

5

Body weight (g)

209.5 ± 6.9

207.6 ± 9.5

207.8 ± 16.3

209.2 ± 10.8

Absolute (g)

 Brain

1.801 ± 0.070

1.839 ± 0.049

1.831 ± 0.026

1.816 ± 0.027

 Thymus

0.279 ± 0.028

0.282 ± 0.021

0.291 ± 0.018

0.276 ± 0.039

 Lungs

0.739 ± 0.058

0.772 ± 0.060

0.756 ± 0.062

0.783 ± 0.049

 Heart

0.717 ± 0.066

0.719 ± 0.052

0.715 ± 0.065

0.702 ± 0.053

 Spleen

0.480 ± 0.027

0.498 ± 0.020

0.476 ± 0.037

0.481 ± 0.029

 Liver

6.007 ± 1.100

5.573 ± 0.301

5.500 ± 0.576

5.518 ± 0.487

 Adrenals

0.034 ± 0.003

0.035 ± 0.002

0.036 ± 0.005

0.038 ± 0.004

 Kidneys

1.417 ± 0.110

1.439 ± 0.096

1.377 ± 0.099

1.369 ± 0.101

 Testes

2.652 ± 0.109

2.754 ± 0.036

2.700 ± 0.233

2.620 ± 0.295

 Pituitary

0.008 ± 0.001

0.009 ± 0.001

0.009 ± 0.002

0.008 ± 0.001

 Thyroid

0.013 ± 0.002

0.016 ± 0.001*

0.015 ± 0.001

0.014 ± 0.001

 Salivary gland

0.401 ± 0.032

0.400 ± 0.013

0.417 ± 0.028

0.416 ± 0.035

 Seminal vesicle

0.512 ± 0.060

0.578 ± 0.075

0.569 ± 0.047

0.570 ± 0.068

 Prostate gland

0.411 ± 0.039

0.442 ± 0.053

0.468 ± 0.036 

0.458 ± 0.026

Relative (%)

 Brain

0.860 ±  0.021

0.887 ±  0.024

0.885 ±  0.068

0.870 ±  0.051

 Thymus

0.133 ±  0.012

0.136 ±  0.009

0.141 ±  0.009

0.132 ±  0.017

 Lungs

0.352 ±  0.023

0.372 ±  0.016

0.364 ±  0.008

0.374 ±  0.013

 Heart

0.342 ±  0.022

0.346 ±  0.016

0.344 ±  0.018

0.335 ±  0.010

 Spleen

0.229 ±  0.006

0.240 ± 0.005 **

0.229 ±  0.005

0.230 ±  0.002

 Liver

2.858 ± 0.429 

2.685 ±  0.069

2.642 ±  0.092

2.634 ±  0.098

 Adrenals

0.016 ±  0.002

0.017 ±  0.001

0.017 ±  0.002

0.018 ±  0.001

 Kidneys

0.676 ±  0.032

0.693 ±  0.024

0.663 ±  0.016

0.654 ±  0.022

 Testes

1.267 ±  0.057

1.329 ±  0.059

1.299 ±  0.044

1.257 ±  0.166

 Pituitary

0.004 ±  0.000

0.004 ±  0.000

0.004 ± 0.001 *

0.004 ±  0.000

 Thyroid

0.006 ±  0.001

0.008  ± 0.000 *

0.007 ±  0.000

0.007 ±  0.000

 Salivary gland

0.191 ±  0.016

0.193 ±  0.004

0.201 ±  0.007

0.199 ±  0.012

 Seminal vesicle

0.245 ±  0.033

0.279 ±  0.037

0.276 ±  0.037

0.272 ±  0.025

 Prostate gland

0.196 ± 0.018 

0.212 ±  0.017

0.226 ±  0.019 *

0.219 ±  0.016

Female

No. of animals

5

5

5

5

Body weight (g)

134.0 ± 6.2

131.8 ± 3.2

133.4 ± 4.2

131.0 ± 4.9

Absolute (g)

 Brain

1.693 ±  0.051

1.678 ±  0.064

1.680 ± 0.047 

1.699 ±  0.035

 Thymus

0.228 ±  0.015

0.233 ±  0.010

0.225 ±  0.020

0.214 ±  0.013

 Lungs

0.625 ±  0.035

0.611 ±  0.060

0.586 ±  0.028

0.566 ±  0.026

 Heart

0.504 ±  0.008

0.507 ±  0.038

0.492 ±  0.026

0.497 ±  0.012

 Spleen

0.347 ±  0.017

0.342 ±  0.009

0.356 ±  0.019

0.344 ±  0.023

 Liver

3.421 ±  0.105

3.446 ±  0.124

3.326 ±  0.150

3.267 ±  0.168

 Adrenals

0.041 ±  0.004

0.043 ±  0.004

0.040 ±  0 .003

0.040 ±  0.002

 Kidneys

0.928 ±  0.075

0.929 ±  0.051

0.949 ±  0.033

0.956 ±  0.037

 Ovaries

0.053 ±  0.004

0.055 ±  0.008

0.055 ±  0.018

0.048 ±  0.012

 Pituitary

0.009 ± 0.001 ^†

0.011 ±  0.002

0.010 ±  0.001

0.009 ±  0.002

 Thyroid

0.010 ±  0.000

0.011 ±  0.001

0.010 ±  0.001

0.011 ±  0.001

 Salivary gland

0.304 ±  0.011

0.290 ±  0.022

0.305 ±  0.014

0.308 ±  0.035

Relative (%)

 Brain

1.266 ±  0.085

1.273 ±  0.030

1.259 ±  0.020

1.298 ±  0.058

 Thymus

0.171 ±  0.012

0.177 ±  0.005

0.168 ±  0.015

0.164 ±  0.012

 Lungs

0.466 ±  0.016

0.463 ±  0.040

0.439 ±  0.018

0.433 ±  0.021

 Heart

0.377 ±  0.016

0.384 ±  0.021

0.369 ±  0.025

0.380 ±  0.015

 Spleen

0.259 ±  0.004

0.260 ±  0.007

0.267 ±  0.009

0.263 ±  0.019

 Liver

2.556 ±  0.106

2.614 ±  0.058

2.493 ±  0.111

2.494 ±  0.114

 Adrenals

0.031 ±  0.004

0.033 ±  0.004

0.030 ±  0.002

0.031 ±  0.001

 Kidneys

0.692 ±  0.026

0.704 ±  0.024

0.711 ±  0.026

0.730 ±  0.032

 Ovaries

0.040 ±  0.002

0.042 ±  0.007

0.041 ±  0.012

0.037 ±  0.008

 Pituitary

0.007 ± 0.000 ^†

0.008 ±  0.001

0.007 ±  0.001

0.007 ±  0.001

 Thyroid

0.008 ± 0.000 

0.008 ±  0.000

0.008 ±  0.000

0.009 ±  0.000*

 Salivary gland

0.224 ±  0.013

0.220 ±  0.013

0.229 ±  0.008

0.236 ±  0.032