Table 6 Haematology of F344/DuCrlCrlj rats treated with titanium dioxide nanoparticles for 90 days

Male

No. of animals

10

10

10

10

RBC (× 10⁶/μl)

9.38 ± 0.19

9.23 ± 0.29

9.21 ± 0.33

9.34 ± 0.18

HGB (g/dL)

15.4 ± 0.2

15.1 ± 0.6

15.0 ± 0.6

15.3 ± 0.3

HCT (%)

45.1 ± 0.8

44.6 ± 1.8

44.0 ± 1.9

44.9 ± 1.1

MCV (fL)

48.0 ± 0.3

48.3 ± 0.7

47.8 ± 0.7

48.1 ± 0.4

MCH (pg)

16.4 ± 0.2

16.4 ± 0.2

16.3 ± 0.2

16.4 ± 0.1

MCHC (g/dL)

34.2 ± 0.3

34.0 ± 0.2

34.1 ± 0.2

34.1 ± 0.2

RET (%)

2.42 ± 0.22

2.51 ± 0.26

2.41 ± 0.19

2.42 ± 0.19

PLT (× 10³/μl)

643 ± 53

621 ± 90

640 ± 27

625 ± 69

WBC (× 10³/μl)

4.01 ± 0.70

3.67 ± 0.69

3.36 ± 0.81

3.58 ± 1.12

Differential cell count

 NEUT (%)

22.7 ± 3.35

27.2 ± 4.75

27.0 ± 2.76

33.5 ± 6.81**

 LYMPH (%)

72.3 ± 3.60

67.7 ± 4.76

67.6 ± 2.83

60.0 ± 7.08**

 MONO (%)

3.64 ± 0.54

3.69 ± 0.53

3.87 ± 0.65

4.34 ± 0.61*

 EO (%)

1.01 ± 0.39

1.10 ± 0.52

1.14 ± 0.32

1.71 ± 1.48

 BASO (%)

0.30 ± 0.08

0.29 ± 0.14

0.41 ± 0.15

0.47 ± 0.18*

 NEUT (× 10³/μl)

0.91 ± 0.21

0.99 ± 0.22

0.90 ± 0.21

1.16 ± 0.32

 LYMPH (× 10³/μl)

2.90 ± 0.52

2.49 ± 0.55

2.28 ± 0.60

2.20 ± 0.86

 MONO (× 10³/μl)

0.15 ± 0.04

0.14 ± 0.03

0.13 ± 0.03

0.16 ± 0.06

 EO (× 10³/μl)

0.04 ± 0.01

0.04 ± 0.03

0.04 ± 0.01

0.06 ± 0.05

 BASO (× 10³/μl)

0.01 ± 0.00

0.01 ± 0.01

0.01 ± 0.00

0.02 ± 0.01

Female

No. of animals

10

10

10

10

RBC (× 10⁶/μl)

8.85 ± 0.18

8.89 ± 0.24

8.89 ± 0.15

8.84 ± 0.31

HGB (g/dL)

15.6 ± 0.3

15.6 ± 0.4

15.6 ± 0.2

15.5 ± 0.5

HCT (%)

45.3 ± 1.1

45.4 ± 1.3

45.4 ± 0.8

45.0 ± 1.6

MCV (fL)

51.2 ± 0.4

51.0 ± 0.3

51.1 ± 0.4

50.9 ± 0.2

MCH (pg)

17.6 ± 0.1

17.5 ± 0.1

17.6 ± 0.1

17.5 ± 0.1**

MCHC (g/dL)

34.4 ± 0.2

34.4 ± 0.3

34.4 ± 0.3

34.4 ± 0.2

RET (%)

2.33 ± 0.19

2.24 ± 0.25

2.41 ± 0.38

2.30 ± 0.44

PLT (× 10³/μl)

677 ± 69

674 ± 34

719 ± 40

701 ± 100

WBC (× 10³/μl)

4.32 ± 1.12

3.89 ± 1.02

4.04 ± 0.41

4.19 ± 0.96

Differential cell count

 NEUT (%)

23.4 ± 6.81

25.8 ± 6.07

25.0 ± 4.14

24.0 ± 3.96

 LYMPH (%)

71.4 ± 7.08

69.3 ± 6.32

70.0 ± 4.24

69.9 ± 4.33

 MONO (%)

3.68 ± 0.61

3.53 ± 0.68

3.53 ± 0.42

3.37 ± 0.63

 EO (%)

2.52 ± 1.48

1.01 ± 0.30

1.15 ± 0.29

2.40 ± 1.63

 BASO (%)

0.47 ± 0.18

0.34 ± 0.07*

0.37 ± 0.11

0.43 ± 0.09

 NEUT (× 10³/μl)

1.03 ± 0.32

0.99 ± 0.28

1.02 ± 0.25

0.99 ± 0.25

 LYMPH (× 10³/μl)

3.07 ± 0.86

2.70 ± 0.80

2.82 ± 0.24

2.94 ± 0.73

 MONO (× 10³/μl)

0.16 ± 0.06

0.14 ± 0.05

0.14 ± 0.02

0.14 ± 0.03

 EO (× 10³/μl)

0.05 ± 0.05

0.04 ± 0.02

0.05 ± 0.01

0.10 ± 0.07*

 BASO (× 10³/μl)

0.02 ± 0.01

0.01 ± 0.00*

0.02 ± 0.01

0.02 ± 0.00