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Table 2 Mean change in systemic inflammation biomarkers following cooking and candle exposure (clean air = reference)†

From: Airway and systemic biomarkers of health effects after short-term exposure to indoor ultrafine particles from cooking and candles – A randomized controlled double-blind crossover study among mild asthmatic subjects

  

Cooking exposure

Candle exposure

  

Coefficient

95% CI

p-value

Coefficient

95% CI

p-value

Cytokines in serum

      
 

IL-1β

-0.14

(-0.31; 0.02)

0.086

-0.17

(-0.32; -0.01)

0.036*

 

IL-8

0.14

(-0.70; 0.97)

0.743

0.18

(-0.63;0.99)

0.660

 

CCL2

3.19

(-11.1; 17.5)

0.660

18.3

(3.97; 32.7)

0.013*

 

TNF-α

-0.42

(-0.78; -0.06)

0.023*

-0.54

(-0.91; -0.17)

0.004*

C-Reactive Protein

      
 

CRP

0.14

(0.03; 0.25)

0.010*

0.10

-0.01; 0.20

0.075

EPCs

      
 

Early

0.74

(-55.7; 57.2)

0.979

-4.55

(-61.7; 52.6)

0.875

 

Late

-2.55

(-33.7; 28.6)

0.871

-9.08

(-41.8; 23.7)

0.585

Gene expression

      
 

IL-8

0.22

(-0.20; 0.63)

0.313

0.39

(-0.03; 0.80)

0.068

 

CCL2

-0.13

(-0.54; 0.29)

0.554

0.01

(-0.41; 0.42)

0.983

 

TNF-α

-0.10

(-0.53; 0.33)

0.637

-0.04

(-0.46; 0.39)

0.855

 

HMOX1

-0.06

(-0.37; 0.25)

0.700

0.01

(-0.30; 0.32)

0.966

 

OGG1

-0.20

(-0.51; 0.09)

0.175

-0.07

(-0.36; 0.22)

0.645

DNA damage

      
 

Strand breaks

-0.007

(-0.04; 0.02)

0.677

0.002

(-0.03; 0.03)

0.918

 

Fpg-sensitive sites

0.06

(0.01; 0.11)

0.024*

-0.02

(-0.07; 0.04)

0.556

  1. Mean changes for CRP and Gene expression correspond to differences on logarithmic scale. Mean changes for DNA damages correspond to differences on the cube root scale
  2. Results are from linear mixed models with no interaction term. Changes are reported from 5 to 24 h post exposure adjusted for baseline (0 h). For cytokines, only CCL2 had complete data; for IL-1β: 167/324, IL-8: 207/324, and TNF-α: 204/324 observations were included in the analyses. Definition of abbreviations: CCL2 = C-C motif chemokine ligand 2, EPCs = Endothelial Progenitor Cells. Fpg = formamidopyrimidine DNA glycosylase. HMOX1 = heme oxygenase (decycling) 1, IL = interleukin, TNF-α = tumor necrosis factor α, OGG1 = oxoguanine DNA glycosylase 1. Cytokines in serum are reported in ln(pg/ml). CRP is reported in ln(ng/ml). EPCs are reported in number of endothelial cells per standard unit. DNA-damages are reported in lesions per 106 base pairs. * The level of significance was assumed at p < 0.05