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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Long-term PM2.5 exposure disrupts corneal epithelial homeostasis by impairing limbal stem/progenitor cells in humans and rat models

Fig. 5

Transcriptome analysis of LSPCs under short-term PM2.5 exposure (A) Limbal epithelium mRNA of rats was extracted and RNA-seq was performed. N = 3 in each group. (B) Heatmap showed the different expression profiling between PBS and PM2.5 groups. (C) The volcano plot indicated the DEGs between PBS and PM2.5 groups. (D) GO analysis of DEGs including biological process, cellular component, and molecular function. (E) KEGG pathway enrichment of DEGs. (F) PPI network analysis of DEGs. LECs_PBS: limbal epithelial cells in the PBS eyedrop administration group; LECs_PM: limbal epithelial cells in the PM2.5 eyedrop administration group; LSPCs: Limbal stem/progenitor cells; RNA-seq: RNA-sequencing; GO: Gene Ontology; KEGG: Kyoto encyclopedia of genes and genomes; DEGs: Differentially expressed genes; PPI: Protein-protein interaction

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Particle and Fibre Toxicology

ISSN: 1743-8977

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