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Fig. 8 | Particle and Fibre Toxicology

Fig. 8

From: Single-cell transcriptome sequencing–based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis

Fig. 8

Secreted MLE-12 EVs adhere to the extracellular matrix to exert their effects. A. Immunofluorescence staining to assess the GPNMB protein levels in the fibrotic ECM, scale bar: 200 μm. B. Elevated GPNMB protein levels in the fibrotic ECM originate from alveolar type II epithelial cells, scale bar: 275 μm. C. Adhesion of Dil-labeled EVs to the ECM, scale bar: 275 μm. D. Increased adhesion of EVs to Fib-ECM compared to Con-ECM. E. Three-dimensional cell migration assay showing that SiO2-EVs migrated from Fib-ECM at 24 h quicker than the control

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Particle and Fibre Toxicology

ISSN: 1743-8977

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