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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments

Fig. 1

Multinucleation induced by aSiNPs both in vivo and in vitro. Pathological analyses of the liver and lung tissue were performed after the mice were intratracheally instilled with aSiNPs (A and B). (A) Representative images of pathological changes in the liver, (a) and (b) control group, (c) and (d) aSiNPs treated group, yellow arrow heads: nuclear fragmentation, vacuolization and necrosis of hepatocytes, (e) multinucleation rate of hepatocytes in proximal region and distal region of central vein, and data were expressed as frequency. (B) Representative images of pathological changes in the lung tissue, (a) control group, (b) aSiNPs treated group, (c) magnified images of multinucleated bronchial epithelial cells (yellow arrow heads). (C) Rate of multinucleated cells induced by aSiNPs in L-02 cells in vitro, and data were expressed as frequency. * p < 0.05 compared with control group using chi-square test

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Particle and Fibre Toxicology

ISSN: 1743-8977

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