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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments

Fig. 3

Effects of aSiNPs on microtubules distribution and cytokinesis (green: microtubule, blue: nucleus, red: fluorescent silica nanoparticles). (A) Abnormal distribution of microtubules induced by aSiNPs (20 µg/ml), (a) normal cells in control group, (b) and (c) multinucleated cells in aSiNPs treated group. Due to the occupation of agglomerated microfilaments, microtubules were distributed in the cytoplasmic in a network form except the region of agglomerated microfilaments. (B) Abnormal cytokinesis induced by aSiNPs (20 µg/ml), (a) chromosome fragments (white arrow heads) in daughter cells, (b) and (c) a thin and long cellular bridge (yellow arrows) connecting the daughter cells

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Particle and Fibre Toxicology

ISSN: 1743-8977

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