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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments

Fig. 4

The expression of proteins related to PI3K/Aurora B pathway and cytokinesis regulation in L-02 cells after 24 h exposure to aSiNPs with different concentrations. (A) Results of western blot analysis. GAPDH was used as an internal control to monitor for equal loading. (B) Relative densitometric analysis of the protein bands was performed and presented. (a) PI3K p85, (b) PI3K 110α, (c) PI3K 110β, (d) p-Aurora B, (e) MKLP1, (f) CYK4, (g) Ect2, (h) Cep55, (i) CHMP2A. (C) Rho activity detected by G-LISA biochem kit. ASiNPs induced the inhibition of PI3K 110β/Aurora B pathway and cytokinesis related regulation proteins in a dose-dependent way. Data were expressed as means ± SD from three independent experiments

* p < 0.05 compared with control group using one-way ANOVA.

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Particle and Fibre Toxicology

ISSN: 1743-8977

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