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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments

Fig. 6

PI3K/Akt pathway activator IGF attenuated the inhibition of Aurora B phosphorylation and centralspindlin cluster induced by aSiNPs. (A) Protein content of p-Akt and p-Aurora B was detected by western blot (a), and results of relative densitometric analysis were presented in (b) and (c), respectively. (B) Relative ratio of CYK4 bound to MKLP1 was detected by co-immunoprecipitaion to reflect the formation of centralspindlin cluster. Data in (A) and (B) were expressed as means ± SD from three independent experiments. * p < 0.05 compared with control group using one-way ANOVA. (C) Rate of multinucleated cells was calculated and data are expressed as frequency. * p < 0.05 compared with control group using chi-square test

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Particle and Fibre Toxicology

ISSN: 1743-8977

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