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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments

Fig. 7

Excessive generation of intracellular ROS in L-02 cells induced by aSiNPs and its relationship with the increase of multinucleation rate. (A) Intracellular ROS level was detected after L-02 cells exposed to different concentrations of aSiNPs using flow cytometry, and the corresponding bar graph was shown. ASiNPs increased the intracellular ROS level in a dose-dependent way. (B) ROS inhibitor NAC effectively reduced the excessive intracellular ROS induced by aSiNPs. Data in (A) and (B) were expressed as means ± SD from three independent experiments. * p < 0.05 compared with control group using one-way ANOVA. (C) ROS inhibitor NAC significantly decreased the rate of multinucleated cells caused by aSiNPs. Rate of multinucleated cells was calculated and data are expressed as frequency. * p < 0.05 compared with control group using chi-square test

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Particle and Fibre Toxicology

ISSN: 1743-8977

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