Fig. 2

The surface charge and hydrodynamic size of ND samples before and after incubation with mouse plasma. The as-prepared particles for intravenous injection were incubated for 30 min with mouse plasma, and zeta potential and hydrodynamic size were measured after redispersing them in DW. (a) The diverse zeta potentials of all as-prepared ND samples for intravenous injection were within a similar range from − 25 mV to -20 mV. (b) Although the hydrodynamic sizes of all as-prepared ND samples for intravenous injection were reduced after incubation with plasma, the pattern of size distribution was consistent. Data are expressed as mean ± SEM for each group (n = 3 per group)