Effect of sp3/sp2 carbon ratio and hydrodynamic size on the biodistribution kinetics of nanodiamonds in mice via intravenous injection

Table 1 Physicochemical properties of NDs used for animal experiments

Physicochemical parameters	Types of ND
Physicochemical parameters	^lowND	^highND
Primary size (nm)	4.93 ± 0.4	4.86 ± 0.3
Surface area (m²/g)	270.2	275.4
sp³/sp² carbon ratio (I_Dia/I_G)	0.55 ± 0.04	1.72 ± 0.17
Hydrodynamic size (nm) in
PBS	629.7 ± 34.0	515.8 ± 28.4
PBS with 3% mouse serum	303.4 ± 2.7	269.0 ± 1.7
Polydispersity index in
PBS	0.33 ± 0.04	0.23 ± 0.02
PBS with 3% mouse serum	0.32 ± 0.01	0.14 ± 0.03
Zeta potential (mV) in
PBS	-5.23 ± 0.22	-23.90 ± 0.53
PBS with 3% mouse serum	-11.60 ± 0.17	-13.20 ± 0.44

ISSN: 1743-8977