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Table 2 The toxicokinetic parameters in the liver, spleen, and lung

From: Effect of sp3/sp2 carbon ratio and hydrodynamic size on the biodistribution kinetics of nanodiamonds in mice via intravenous injection

Parameters

Cmax (µg)

Tmax (h)

AUC0 − 1d

AUC0 − 7d

AUC0 − 28d

lowND

 - Liver

309.3 ± 27.3

672

175.1

1872.0

8269.0

 - Spleen

81.4 ± 21.7

168

33.7

416.2

1955.0

 - Lung

295.8 ± 44.7

0.5

262.6

1385.0

4735.0

highND

 - Liver

325.5 ± 80.9

168

212.2

2150.0

8735.0

 - Spleen

106.9 ± 29.8

672

24.6

333.4

2168.0

 - Lung

282.4 ± 69.3

0.5

211.8

962.5

3132.0

  1. Data were expressed as mean ± SEM. The AUC was calculated based on concentration(µg)/organ
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Particle and Fibre Toxicology

ISSN: 1743-8977

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