Table 10 Summary of histopathological findings for neoplastic lesions at 104-weeks of the experimental period
Test article | Male | Female | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nontreatment | Control | MWNT-7 | VGCF™-H | Nontreatment | Control | MWNT-7 | VGCF™-H | |||||||||
Total dose (mg/kg) | – | 0 | 0.128 | 0.64 | 3.2 | 0.128 | 0.64 | 3.2 | – | 0 | 0.128 | 0.64 | 3.2 | 0.128 | 0.64 | 3.2 |
No. of animals/group | 30 | 30 | 30 | 30 | 39 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 |
Lung/bronchial | ||||||||||||||||
Adenoma, bronchiolo-alveolar | 0 | 4 | 1 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 3 | 0 | 0 | 1 | 0 | 2 |
Adenocarcinoma, bronchiolo-alveolar | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Carcinoma, adenosquamous | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Total adenoma and/or carcinoma | 0 | 4 | 0 | 0 | 2 | 2 | 0 | 1 | 1 | 0 | 3 | 1 | 1 | 1 | 0 | 2 |
Thoracic cavity | ||||||||||||||||
Mesothelioma, malignant | 0 | 0 | 1 | 18## | 37## | 0 | 0 | 2 | 0 | 0 | 2 | 1 | 22## | 0 | 0 | 0 |