Table 11 Histopathological findings: summary of neoplastic (benign) or neoplastic (malignant) in male
Test article | Nontreatment | Control | MWNT-7 | VGCF™-H | ||||
|---|---|---|---|---|---|---|---|---|
Total dose (mg/kg) | 0.13 | 0.64 | 3.2 | 0.13 | 0.64 | 3.2 | ||
Number of animals | 30 | 30 | 30 | 30 | 39 | 30 | 30 | 30 |
Heart | ||||||||
Schwannoma, intramural | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Schwannoma, subendocardial | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Other lymph node | [2]b | [3]b | [3]b | [4]b | [3]b | [3]b | [5]b | [4]b |
Hemangioma | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Spleen | ||||||||
Fibroma | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pituitary | [12]b | [11]b | [10]b | [9]b | [3]b | [11]b | [12]b | [12]b |
Adenoma, pars distalis | 9 | 9 | 6 | 5 | 3 | 8 | 11 | 10 |
Adenoma, pars intermedia | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Carcinoma, pars distalis | 0 | 0 | 2 | 1 | 0 | 0 | 1 | 0 |
Craniopharyngioma, malignant | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Thyroid | [10]b | [9]b | [9]b | [8]b | [1]b | [6]b | [7]b | [7]b |
Adenoma, C-cell | 6 | 7 | 8 | 5 | 1 | 6 | 4 | 6 |
Adenoma, follicular cell | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Carcinoma, C-cell | 2 | 1 | 1 | 3 | 0 | 1 | 1 | 2 |
Carcinoma, follicular cell | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Adrenal | [3]b | [2]b | [1]b | [1]b | [1]b | [4]b | [3]b | [1]b |
Ganglioneuroma, benign | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pheochromocytoma, benign | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 |
Pheochromocytoma, complex, malignant | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pheochromocytoma, malignant | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Nasal cavity | [1]b | [1]b | ||||||
Adenocarcinoma | 0 | 1 | ||||||
Tongue | [1]b | |||||||
Carcinoma, squamous cell | 1 | |||||||
Stomach | [3]b | [3]b | [1]b | [2]b | [6]b | [1]b | [1]b | |
Adenocarcinoma | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
Leiomyosarcoma | 0 | 0 | 0 | 0 | 1 | 1 | 0 | |
Jejunum | [1]b | [3]b | [1]b | [1]b | [1]b | |||
Gastrointestinal stromal tumor | 0 | 0 | 0 | 0 | 0 | |||
Leiomyosarcoma | 0 | 1 | 0 | 0 | 0 | |||
Cecum | [3]b | [3]b | [2]b | |||||
Leiomyoma | 0 | 1 | 0 | |||||
Pancreas | [1]b | [1]b | [2]b | [3]b | [4]b | [2]b | ||
Adenoma, islet cell | 0 | 0 | 0 | 1 | 0 | 0 | ||
Carcinoma, islet cell | 0 | 1 | 0 | 0 | 2 | 1 | ||
Liver | ||||||||
Adenoma, hepatocellular | 3 | 0 | 1 | 0 | 0 | 2 | 0 | 0 |
Carcinoma, hepatocellular | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Kidney | ||||||||
Adenoma | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Hemangioma | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Carcinoma, transitional cell | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Urinary bladder | [2]b | [1]b | [1]b | [2]b | ||||
Papilloma, transitional cell | 0 | 0 | 0 | 1 | ||||
Testis | [26]b | [27]b | [26]b | [23]b | [24]b | [27]b | [26]b | |
Adenoma, leydig cell | 26 | 25 | 24 | 21 | 20 | 25 | 27 | 26 |
Prostate | [1]b | [1]b | [1]b | [1]b | ||||
Adenoma | 0 | 1 | 0 | 0 | ||||
Adenocarcinoma | 0 | 0 | 0 | 0 | ||||
Prep./ Clit. gland | [3]b | [2]b | [3]b | [2]b | ||||
Adenoma | 0 | 0 | 0 | 2 | ||||
Adenocarcinoma | 3 | 2 | 2 | 0 | ||||
Mammary gland | [2]b | [1]b | [1]b | [3]b | [1]b | [1]b | [2]b | |
Fibroadenoma | 2 | 0 | 1 | 0 | 0 | 1 | 1 | |
Thoracic wall | [1]b | [3]b | [12]b | [36]b | [1]b | |||
Osteosarcoma | 0 | 1 | 0 | 0 | 0 | |||
Skin/subcutis | [7]b | [9]b | [6]b | [9]b | [2]b | [6]b | [11]b | [5]b |
Fibroma | 6 | 6 | 3 | 4 | 0 | 4 | 6 | 1 |
Keratoacanthoma | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 1 |
Lipoma | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Papilloma, squamous cell | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 0 |
Trichoepithelioma | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Carcinoma, squamous cell | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Skin/subcutis | ||||||||
Fibrosarcoma | 0 | 0 | 0 | 1 | 1 | 0 | 2 | 1 |
Hemangiosarcoma | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Malignant fibrous histiocytoma | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Malignant schwannoma | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Rhabdomyosarcoma | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Sarcoma, NOS | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Zymbal's gland | [1]b | [1]b | [2]b | [1]b | ||||
Carcinoma | 1 | 1 | 2 | 1 | ||||
Brain | [3]b | [5]b | [5]b | [2]b | [1]b | [3]b | [3]b | [3]b |
Astrocytoma, malignant, low grade | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Tumor, granular cell, malignant | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Invasion (pituitary: carcinoma pars distalis) | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 |
Abdominal cavity | [1]b | [2]b | [2]b | [2]b | [4]b | [1]b | [3]b | |
Mesothelioma, malignant | 1 | 2 | 2 | 2 | 4 | 1 | 3 | |
Pinna | [1]b | |||||||
Neural crest neoplasm | 1 | |||||||
All sites | [4]b | [6]b | [4]b | [6]b | [2]b | [7]b | [5]b | [6]b |
Histiocytic sarcoma | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
Large granular lymphocyte leukemia | 4 | 4 | 4 | 6 | 0 | 7 | 4 | 4 |
Lymphocytic lymphoma | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2 |
Myeloid leukemia | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cranial bone | [1]b | |||||||
Chondrosarcoma | 1 | |||||||
Lumber vertebra | [1]b | |||||||
Osteosarcoma | 1 | |||||||
Sternum | ||||||||
Osteosarcoma | ||||||||